Key publications
Staels W, Berthault C, Bourgeois S, Laville V, Lourenço C, De Leu N, Scharfmann. Comprehensive alpha, beta, and delta cell transcriptomics reveal an association of cellular aging with MHC class I upregulation.
Mol Metab. 2024 Jul 14:87:101990.
PubMed Abstract
Bourgeois S, Coenen S, Degroote L, Willems L, Van Mulders A, Pierreux J, Heremans Y, De Leu N, Staels W. Harnessing beta cell regeneration biology for diabetes therapy. Trends Endocrinol Metab. 2024 Apr 20
PubMed Abstract
Staels W, Verdonck Y, Heremans Y, Leuckx G, De Groef S, Heirman C, de Koning E, Gysemans C, Thielemans K, Baeyens L, Heimberg H, De Leu N: Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation.
Diabetologia 61(8), 1804-1810, 2018
PubMed Abstract
Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, Cools M, Keshet E, Dor Y, Heimberg H, De Leu N: Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice.
Diabetologia 60(6), 1051-1056, 2017
PubMed Abstract
Yuchi Y, Cai Y, Legein B, De Groef S, Leuckx G, Coppens V, Van Overmeire E, Staels W, De Leu N, Martens G, Van Ginderachter JA, Heimberg H, Van de Casteele M: Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury.
Diabetes 64:3218-3228, 2015
PubMed Abstract
Van de Casteele M, Leuckx G, Cai Y, Yuchi Y, Coppens V, De Groef S, Van Gassen N, Baeyens L, Heremans Y, Wright CV, Heimberg H: Partial duct ligation: β-cell proliferation and beyond.
Diabetes 63:2567-2577, 2014
PubMed Abstract
D'Hoker J, De Leu N, Heremans Y, Baeyens L, Minami K, Ying C, Lavens A, Chintinne M, Stangé G, Magenheim J, Swisa A, Martens G, Pipeleers D, Van de Casteele M, Seino S, Keshet E, Dor Y, Heimberg H: Conditional hypovascularization and hypoxia in islets does not overtly influence adult beta cell mass and function.
Diabetes 62:4165-4173, 2013
PubMed Abstract
Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van De Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Sharfmann R, Gradwohl G, Heimberg H: Beta cell progenitors can be generated from endogenous progenitors in injured adult mouse pancreas.
Cell 132:197-207, 2008
PubMed Abstract
Mellitzer G, Bonné S, Luco, RF, Van De Casteele, M, Lenne, N, Collombat, P, Mansouri, A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G. and Heimberg H.: IA1 is Ngn3-dependent and essential for differentiation of the endocrine pancreas.
EMBO J 25:1344-1352, 2006
PubMed Abstract
Heremans Y, Van De Casteele M, in 't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H: Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.
J Cell Biol 159:303-311, 2002
PubMed Abstract
Heimberg H, Bouwens L, Heremans Y, Van De Casteele M, Lefebvre V, Pipeleers D: Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1.
Diabetes 49:571-579, 2000
PubMed Abstract
Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F: The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Proc Natl Acad Sci USA 93:7036-7041, 1996
PubMed Abstract
Devos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F: Human and Rat Beta-Cells Differ in Glucose-Transporter but Not in Glucokinase Gene-Expression.
J Clin Invest 96:2489-2495, 1995
PubMed Abstract
Heimberg H, De Vos A, Vandercammen A, Vanschaftingen E, Pipeleers D, Schuit F: Heterogeneity in Glucose Sensitivity among Pancreatic Beta-Cells Is Correlated to Differences in Glucose Phosphorylation Rather Than Glucose- Transport.
EMBO J 12:2873-2879, 1993
PubMed Abstract