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Key publications

Staels W, Verdonck Y, Heremans Y, Leuckx G, De Groef S, Heirman C, de Koning E, Gysemans C, Thielemans K, Baeyens L, Heimberg H, De Leu N: Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation.
Diabetologia 61(8), 1804-1810, 2018
PubMed Abstract

Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, Cools M, Keshet E, Dor Y, Heimberg H, De Leu N: Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice.
Diabetologia 60(6), 1051-1056, 2017
PubMed Abstract

Yuchi Y, Cai Y, Legein B, De Groef S, Leuckx G, Coppens V, Van Overmeire E, Staels W, De Leu N, Martens G, Van Ginderachter JA, Heimberg H, Van de Casteele M: Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury.
Diabetes 64:3218-3228, 2015
PubMed Abstract

Van de Casteele M, Leuckx G, Cai Y, Yuchi Y, Coppens V, De Groef S, Van Gassen N, Baeyens L, Heremans Y, Wright CV, Heimberg H: Partial duct ligation: β-cell proliferation and beyond.
Diabetes 63:2567-2577, 2014
PubMed Abstract

D'Hoker J, De Leu N, Heremans Y, Baeyens L, Minami K, Ying C, Lavens A, Chintinne M, Stangé G, Magenheim J, Swisa A, Martens G, Pipeleers D, Van de Casteele M, Seino S, Keshet E, Dor Y, Heimberg H: Conditional hypovascularization and hypoxia in islets does not overtly influence adult beta cell mass and function.
Diabetes 62:4165-4173, 2013
PubMed Abstract

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van De Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Sharfmann R, Gradwohl G, Heimberg H: Beta cell progenitors can be generated from endogenous progenitors in injured adult mouse pancreas.
Cell 132:197-207, 2008
PubMed Abstract

Mellitzer G, Bonné S, Luco, RF, Van De Casteele, M, Lenne, N, Collombat, P, Mansouri, A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G. and Heimberg H.: IA1 is Ngn3-dependent and essential for differentiation of the endocrine pancreas.
EMBO J 25:1344-1352, 2006
PubMed Abstract

Heremans Y, Van De Casteele M, in 't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H: Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.
J Cell Biol 159:303-311, 2002
PubMed Abstract

Heimberg H, Bouwens L, Heremans Y, Van De Casteele M, Lefebvre V, Pipeleers D: Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1.
Diabetes 49:571-579, 2000
PubMed Abstract

Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F: The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Proc Natl Acad Sci USA 93:7036-7041, 1996
PubMed Abstract

Devos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F: Human and Rat Beta-Cells Differ in Glucose-Transporter but Not in Glucokinase Gene-Expression.
J Clin Invest 96:2489-2495, 1995
PubMed Abstract

Heimberg H, De Vos A, Vandercammen A, Vanschaftingen E, Pipeleers D, Schuit F: Heterogeneity in Glucose Sensitivity among Pancreatic Beta-Cells Is Correlated to Differences in Glucose Phosphorylation Rather Than Glucose- Transport.
EMBO J 12:2873-2879, 1993
PubMed Abstract